Jason Wachob is the Founder and Co-CEO of mindbodygreen and the author of Wellth.
Image by Dale Bredesen, M.D.
April 15, 2025
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It's exciting to see more and more experts embracing lifestyle as a powerful tool to prevent cognitive decline. After all, when it comes to brain health, it's important to mitigate potential issues before they manifest with symptoms. Translation: With cognitive decline, it's best to intervene as early as you can.
Enter neurologist Dale Bredesen, M.D., author of the New York Times bestselling bookThe End of Alzheimer's. He has made it his mission to provide actionable advice on cognitive decline and help people truly optimize their brain health—regardless of their age or cognitive status.
On this episode of the mindbodygreen podcast, Bredesen rattles off some less obvious factors that can significantly affect your brain health. Make sure you have the below on your radar:
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1.
Your oral microbiome
You might be familiar with how the gut microbiome affects basically every function in your body (including brain health), but did you know your oral microbiome is just as critical? It's true: Your mouth, after all, is the gateway to your body and the beginning of your gastrointestinal tract. "So I recommend everyone check out your oral microbiome," advises Bredesen. (He suggests using a service like MyPerioPath.) "Do you have P. gingivalis, T. denticola, prevotella intermedia, F. nucleatum? These organisms are being found in the brain' they're being found in the plaques of coronary arteries… These things are impacting us systemically1."
Vitamin D is one impressive micronutrient: The sunshine vitamin influences not only brain development4 but also everyday brain function5; it even works to protect your brain as you age5. In fact, one meta-analysis6 conducted in 2019 that reviewed 11 studies on a total of 21,784 participants found significant associations between vitamin D deficiency and both dementia and Alzheimer's disease.
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It's something Bredesen sees all the time in his own practice. "It's surprisingly common to see people come in with cognitive decline and their vitamin D level is 19 or 20 [ng/mL]." For reference, a blood level of 30 ng/mL7 is often considered the minimum cutoff for "normal" vitamin D status, but many experts believe a level of at least 50 ng/mL is crucial to keep your body healthy and feel your best. If you'd like to keep your levels up to snuff, check out our vetted list of high-quality vitamin D supplements.
A few unsuspecting factors can play a significant role when it comes to brain health. Of course, you can supercharge your brain health in myriad ways (polyphenol-rich veggies, anyone?), so consider this another helpful list to have on your radar.
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The Journal of Clinical Endocrinology & Metabolism
The Journal of Clinical Endocrinology & Metabolism is the world's leading peer-reviewed journal for the dissemination of original research as it relates to the clinical practice of endocrinology, diabetes, and metabolism.
JAMA, published continuously since 1883, is an international peer-reviewed general medical journal. JAMA is a member of the JAMA Network, a consortium of peer-reviewed, general medical and specialty publications.
PubMed® comprises more than 34 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full text content from PubMed Central and publisher web sites.