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The U.S. Surgeon General Changes Its Alcohol Advisory Due To This Major Risk

Ava Durgin
Author:
January 17, 2025
Ava Durgin
Assistant Health Editor
By Ava Durgin
Assistant Health Editor
Ava Durgin is the Assistant Health Editor at mindbodygreen. She is a recent graduate from Duke University where she received a B.A. in Global Health and Psychology. In her previous work, Ava served as the Patient Education Lead for Duke Hospital affiliated programs, focusing on combating food insecurity and childhood obesity.
Image by Martí Sans / Stocksy
January 17, 2025

For years, we’ve heard the same story: A glass of wine is good for your heart. A cold beer helps you unwind. Moderate drinking? Totally fine—maybe even healthy.

But the U.S. Surgeon General just dropped a sobering update that challenges everything we thought we knew about alcohol and health. The latest advisory reveals a direct, science-backed link between alcohol consumption and cancer. And this isn't just about heavy drinking—even that “harmless” glass of wine could be raising your cancer risk.

Let’s dive into the science behind this groundbreaking advisory and explore how alcohol really affects your body.

Alcohol: A leading cause of preventable cancer

Here’s the hard truth: Alcohol is the third leading preventable cause of cancer in the U.S., right behind tobacco use and obesity. According to the Surgeon General’s 2025 advisory1, alcohol use contributes to nearly 100,000 cancer cases and about 20,000 cancer deaths every year in the United States.

To put that in perspective, alcohol-related cancer deaths claim more lives annually than alcohol-related car crashes (~20,000 vs. ~13,500). Even more alarming? On average, people who die from alcohol-related cancers lose about 15 years of their lives. Altogether, these premature deaths add up to roughly 305,000 years of lost potential every year, highlighting just how deeply alcohol-related cancers impact individuals, families, and communities.

Globally, alcohol was linked to 741,300 cancer cases in 2020, and here’s the kicker: 185,100 of those cases were tied to moderate drinking—defined as just two drinks a day or fewer.

The alcohol-cancer connection: What does the science say?

So how exactly does alcohol cause cancer? The science is clear and well-established. Alcohol increases cancer risk through multiple biological pathways:

  1. DNA damage from acetaldehydeWhen you drink alcohol, your body metabolizes ethanol into acetaldehyde, a toxic, cancer-causing compound. Acetaldehyde binds to DNA, causing mutations that can trigger uncontrolled cell growth—aka cancer.
  2. Oxidative stress and inflammationAlcohol generates reactive oxygen species (ROS)—unstable molecules that damage cells, proteins, and DNA through oxidation. This leads to chronic inflammation, a known driver of cancer development.
  3. Hormone disruptionAlcohol interferes with hormone regulation, particularly by increasing estrogen levels. Elevated estrogen is strongly linked to a higher risk of breast cancer.
  4. Enhanced absorption of carcinogensAlcohol acts as a solvent for other harmful substances. For example, when combined with tobacco, alcohol helps carcinogens penetrate the body’s tissues, amplifying the risk for mouth and throat cancers.

These mechanisms explain why alcohol is causally linked to at least seven types of cancer:

  • Breast cancer (in women)
  • Colorectal cancer
  • Liver cancer
  • Esophageal cancer
  • Oral cavity (mouth) cancer
  • Pharyngeal (throat) cancer
  • Laryngeal (voice box) cancer

How much alcohol is too much? (Spoiler: less than you think)

It’s tempting to think that only heavy drinkers are at risk, but the data says otherwise. For some cancers, the risk starts increasing at just one drink per day.

Breast cancer 

  • Drinking just one drink per day raises the risk of breast cancer by 10%.
  • More than two drinks daily increases this risk by 32%.

Colorectal cancer

  • Moderate drinking (1.5–4 drinks/day) raises colon cancer risk by 17%.
  • Heavy drinking (4+ drinks/day) increases this risk by 44%.

Mouth, throat, and esophageal cancers

  • Light drinking (~1 drink/day) raises mouth cancer risk by 40%.
  • Moderate drinking (1.5–4 drinks/day) raises the risk of esophageal cancer by an astonishing 123% and oral/throat cancers by 83%. 
  • Heavy drinkers face a 5x higher risk for oral and throat cancers.

The bottom line? Any amount of alcohol increases your cancer risk. And while heavier drinking causes a sharper spike, even light drinking isn’t without consequences.

Why haven’t we heard more about this?

Despite decades of research, public awareness about alcohol’s link to cancer is shockingly low. In a 2019 survey:

  • 91% of Americans recognized tobacco as a cancer risk.
  • 89% recognized radiation exposure.
  • 81% knew asbestos was dangerous.
  • Only 45% knew alcohol increases cancer risk.

This gap in understanding is partly due to how alcohol is marketed. Messages about "responsible drinking" or the heart-health benefits of red wine have overshadowed the risks. Meanwhile, warnings about alcohol and cancer have been notably absent—until now.

So, should you quit drinking?

That’s a personal choice, but here’s what the science suggests: Less is better.

  • Up to 1 drink per day for women
  • Up to 2 drinks per day for men

Yet, the Surgeon General’s advisory highlights that 17% of alcohol-related cancer deaths occur within these so-called “safe” limits. Reducing your alcohol intake—or cutting it out altogether—can meaningfully lower your cancer risk.

Practical steps to lower your risk

If you’re rethinking your drinking habits, here are science-backed ways to protect your health:

  1. Understand the standard drink – A standard drink is:5 oz of wine12 oz of beer (5% alcohol)1.5 oz of distilled spirits
  2. Track your drinking – Keep a log to understand how much you're really consuming. (That oversized wine glass might be holding two servings, not one!)
  3. Set drink-free days – Designate alcohol-free days during the week. "Dry January" doesn’t have to end in February.
  4. Opt for low-ABV options – Choose beverages with lower alcohol content or explore alcohol-free options. Check out my favorite zero-proof pineapple smash cocktail as a delicious alternative! 
  5. Consider your family history – If cancer runs in your family, lowering alcohol intake may be even more important.
  6. Change your perspective – Reducing alcohol intake doesn’t have to feel like giving something up. Rather, you are adding to your life—a life that can be just as fun, if not more rewarding, offering clearer focus, better sleep, and a deeper sense of well-being.

The takeaway

Alcohol has long been marketed as a harmless—or even healthy—part of our social lives. However, the scientific evidence is clear: alcohol consumption increases cancer risk.

The latest Surgeon General’s advisory is a wake-up call to rethink how alcohol fits into our health decisions. Being informed about the risks allows you to make decisions that support your long-term health. Whether that means reducing how much you drink or simply becoming more mindful of your habits, small changes can lower your risk and contribute to a longer, healthier life.

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