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The Holistic Ingredient An MD Uses For Deeper Sleep & A Gentler Wakeup

Author:

Emma Loewe

May 05, 2023

By Emma Loewe

mbg Contributor

Emma Loewe is the former Sustainability and Health Director at mindbodygreen. She is the author of "Return to Nature: The New Science of How Natural Landscapes Restore Us" and the co-author of "The Spirit Almanac: A Modern Guide To Ancient Self Care." Emma received her B.A. in Environmental Science & Policy with a specialty in environmental communications from Duke University. In addition to penning over 1,500 mbg articles on topics from the water crisis in California to the rise of urban beekeeping, her work has appeared on Grist, Bloomberg News, Bustle, and Forbes.

Image by ALEXEY KUZMA / Stocksy

May 05, 2023

The human brain, unfortunately, doesn't come with an on-off switch. Getting into sleep mode after a long day is a gradual process that involves physiological changes (slower heart rate, reduced temperature and blood pressure) as well as shifts in sleep-regulating neurotransmitters—gamma-aminobutyric acid (GABA for short) being one of the biggies.

This chemical messenger's job is to tell the body to relax and calm down following any outside triggers or excitement. Needless to say, when levels of it are off, our sleep tends to suffer.

The research on PharmaGABA® for sleep

Low GABA levels—which can be caused by genetics, certain medication, poor diet, and just everyday stressors—have been associated with long-term sleep issues 1 and difficulty falling asleep. While eating a healthy diet, exercising, and doing calming activities like meditation can help bring levels back into balance, there's also a premium ingredient that's been shown to support healthy GABA levels and help people fall asleep fast.*

sleep support+

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Meet PharmaGABA®, a version of the GABA neurotransmitter that's manufactured using a fermentation process that isn't too dissimilar to the one used to make cheese, wine, and other fermented foods.

Acclaimed integrative medicine doctor Robert Rountree, M.D., has been using the bioactive GABA to help clients sleep for decades, to great success.*

"It's an amazing substance," Rountree previously told mindbodygreen's co-CEO Jason Wachob. "It's been shown to bind to the same GABA aminobutyric acid receptors in the brain that help us calm down and relax."*

Rountree explained that some of his medical colleagues were at first doubtful that manufactured GABA could have the same effects as the real deal, but recent research has shown otherwise. In one 2018 double-blind, placebo-controlled trial on 40 patients who reported difficulty falling asleep, a four-week GABA regimen 2 was shown to decrease their sleep latency (the time it takes someone to fall asleep) and increase sleep efficacy (the percentage of time in bed someone actually spends sleeping).*

"I wouldn't say that it knocks you out," Rountree clarifies. "It just makes you feel calmer and more relaxed, and there are studies showing that it actually affects brainwaves."*

In one of those clinical trials, EEG measurements found that GABA, compared to water and L-theanine (another amino acid that's thought to promote sleep), significantly increased the brain's alpha waves 3 (relaxing) and decreased its beta waves (stimulating) within an hour of administration.* In short, Rountree says? "It's the real deal."

Sleep aids that pair well with PharmaGABA®

When mbg formulated its first sleep supplement, sleep support+, we knew PharmaGABA® had to be part of the formula.

sleep support+

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To boost its relaxation chops, we paired PharmaGABA® with a bioavailable form of magnesium, magnesium bisglycinate.* The mineral actually binds to the same receptors in the brain that GABA does, setting off a similarly calming reaction throughout the body.* The formula is topped off with jujube, a fruit that's long been prized in traditional Chinese medicine for its ability to improve sleep quality 4 and enhance daytime functioning.*

"[Magnesium and PharmaGABA®] can enhance the ability to fall asleep, but they also improve sleep quality, and so does jujube,"* Rountree said at the summit. "This is kind of an ideal formula for both."

The takeaway

Unlike other popular supplements like melatonin, sleep support+ doesn't just help people fall asleep faster. It's designed to improve all-around sleep quality, too, leading to a difference that you can feel the next morning.* While it's not quite an on-off switch for the brain, it might just be the next best thing.

If you are pregnant, breastfeeding, or taking medications, consult with your doctor before starting a supplement routine. It is always optimal to consult with a health care provider when considering what supplements are right for you.