13 Best Heart Supplements For Cardiovascular Function & Well-Being

Do you take your heart for granted? I know I could probably appreciate mine more. This incredible organ pumps approximately five to six liters1 of blood throughout your body per minute at rest! Now, consider how much it’s doing for you as you’re jogging to catch the train, hitting your favorite spin class, or dancing the night away with friends.

From a holistic perspective, the collective actions we take on a daily basis to help support our hearts (e.g., physical activity, getting adequate restful sleep, proper hydration, a well-balanced and nutrient-dense diet), there are additional strategies we can incorporate into our daily routine to help support our heart longevity—such as dietary supplementation.* 

Omega-3s—specifically, marine omega-3 fatty acids EPA & DHA found primarily in fish and fish oil supplements—are basically synonymous with heart health and longevity.*

From supporting healthy triglyceride levels2 to enhancing circulation, these holistic (and seriously under consumed) healthy fats deliver profound cardiovascular benefits3 that have a lasting impact on your heart health.* Consuming both EPA and DHA has even been found to lower blood pressure, which the FDA recognizes as a way4 to reduce the risk of hypertension, a risk factor for coronary heart disease (CHD).*†

For optimal heart health benefits, find a sustainably sourced fish oil supplement that’s tested for purity and delivers a minimum of 500 milligrams (ideally, closer to 1,000-1,500 milligrams, or 1-1.5 grams) of EPA plus DHA.

Plant sterols and plant stanols are phytosterols—i.e., bioactive compounds intrinsic to certain plants (like vegetable oils, nuts, and seeds), albeit in small amounts. Thanks to their structural similarities to cholesterol, they help promote healthy cholesterol levels. In fact, randomized controlled trial research5 demonstrates that 1,800 milligrams (i.e., 1.8 grams) plant sterols and/or stanols a day was found to significantly reduce total and LDL (“bad”) over several weeks.* The FDA also recognizes that at least 800 milligrams a day of plant sterols and stanols as part of a diet low in saturated fat and cholesterol, may reduce the risk of heart disease.‡

Plant sterol and stanol supplements can be found in capsule, tablet, and gelcap form, typically in doses up to two to three grams.

Coenzyme Q, aka CoQ10, is required for cellular energy production and also functions as an antioxidant that scavenges free radicals, giving it a number of beneficial actions throughout the body—including cardioprotective properties. It resides in the body’s most metabolically active organs (including the heart) and has been found to support major cardiovascular health factors6, such as endothelial function and healthy nitric oxide levels, according to a 2021 Antioxidants review.*

CoQ10 supplements come in capsules, chewable tablets, softgels, liquids, and more. Look for a product with ubiquinol (which has superior bioavailability7 and bioactivity) in doses of 100 to 200 milligrams, which promote heart health benefits.*

Bergamot orange is a type of yellow citrus fruit that grows primarily in southern Italy. It’s rich in flavonoids and other unique antioxidants, which help protect cardiovascular function and promote a healthy heart. In a 2019 Food Science & Nutrition review, bergamot orange (extract, juice, or oil) was found to promote healthy cholesterol levels by helping reduce total cholesterol, LDL (“bad”) cholesterol, and triglycerides, while increasing HDL (“good”) cholesterol.* Other studies have found this citrus fruit to support healthy blood pressure and blood glucose levels, and one randomized controlled trial published by Nutrients in 2022 found that combining bergamot and artichoke extracts led to a reduction in waist circumference and fat tissue8.* 

Exclusively found in plants, soluble fiber is a complex carbohydrate that is digested (but not absorbed) into a gel-like substance that helps bind to cholesterol in the small intestine and remove it before it enters or re-enters the bloodstream. 

According to a 2018 systematic review and meta-analysis from The American Journal of Clinical Nutrition, consuming two to ten grams of dietary fiber per day is associated with significant decreases in LDL and total cholesterol levels. In a 2016 study, a six-gram dose of guar bean fiber, specifically, was found to also increase levels of HDL (“good”) cholesterol levels when taken with meals three times daily.*

Targeted soluble fiber supplements with high quality and meaningful amounts of fiber are typically found in powder form. Look for a clean formula with organic ingredients that delivers five to six grams of fiber per serving.

Used in Chinese traditional medicine for centuries, red yeast rice (RYR) is a fermented rice that contains a unique phytonutrient compound called monacolin K that helps support cardiovascular health in a number of ways. 

According to a 2017 systematic review published in Critical Reviews in Food Science and Nutrition, RYR has been found to reduce total and LDL cholesterol levels10, as well as blood pressure and triglycerides.* A 2019 review from the Chinese Journal of Natural Medicine also found red yeast rice to be helpful in bolstering endothelial function11 and combating oxidative stress.*

Made from the seeds of wine grapes, grape seed extract (GSE) is rich in antioxidants, including proanthocyanidins, of which it’s one of the best sources. According to a 2021 Nutrients study, GSE has been shown to help increase blood flow, combat oxidative stress, and reduce heart rate, as well as modulate healthy endothelial function and blood pressure12.*

GSE can be found in liquid, capsule, and powder form. Look for a 150- to 300-milligram dose to optimize heart health benefits.*

Beetroots (aka red beets) are packed with a number of phytonutrients that help promote heart health. According to a 2015 Nutrients review, its betalain metabolites are especially beneficial for combating oxidative stress13, protecting lipids from oxidation, and promoting healthy blood flow. 

It has also been found to lower blood pressure14 and promote nitric oxide production, as demonstrated in a 2017 Advances in Nutrition review, which makes it a great option for athletes looking to optimize their cardiovascular function during exercise (though anyone can benefit from its stellar cardioprotective properties).* You can find red beetroot in chew, capsule, liquid, and powder form.

Pantethine15 is a derivative of pantothenic acid, aka vitamin B5. Collectively, B vitamins are critical for cellular energy production, cardiometabolic pathways, methylation function, and overall heart health. Pantethine has been found to help promote healthy cholesterol 16and triglyceride levels.* In a 2017 study on healthy adults, pantethine was also found to promote healthy inflammatory pathways directly correlated with cardiovascular health and longevity.* 

Doses up to 900 milligrams have been found effective in supporting overall heart function. As for form? Pantethine can be found in capsules, tablets, and softgels.

An essential mineral critical to whole-body health, magnesium is a vital nutrient that’s been found to help maintain a steady heart rate and healthy blood pressure. According to a 2017 meta-analysis published in Neuroscience Research, magnesium helps promote blood flow by bolstering endothelial function17 and supporting vasodilation. Essentially, it helps your heart muscles relax so it can beat in a healthy rhythm. 

Vitamin K2, aka menaquinone, is a specific form of vitamin K that supports musculoskeletal and cardiovascular health. According to a 2021 BMJ Journals review, it helps regulate calcium homeostasis by binding calcium to bone and stopping it from binding to arterial tissue (which can cause cardiovascular concerns down the road).* Through this action, vitamin K2 also promotes endothelial function and healthy blood flow.*

Vitamin K2 supplements come in capsule, softgel, and gummy form. For best cardiovascular results, consider taking a dose of 180 micrograms and up to 2,000 mcg (i.e., two milligrams) or more.*

Folate is an essential B vitamin (B9) that, amongst other essential functions in the body, enables the methylation cycle to run smoothly, as the body requires active folate to help convert homocysteine to methionine. Without sufficient folate, homocysteine levels can build up over time, leading to cardiovascular, neurological, and/or immune health issues.

Getting enough folate daily is absolutely critical to keep homocysteine levels in check. The problem is that folks with the MTHFR gene variant (i.e., approximately 50% of the U.S. population!) have a difficult time converting the folate (from food) or folic acid (from certain supplements) into an active form their body can use to support a healthy methylation cycle. 

This is where bioavailability comes in! The activated, methylated form of folate—5-methyltetrahydrofolate (5-MTHF)—can be taken daily to ensure that your body is getting the most optimized form of folate to comprehensively support your methylation cycle and overall cardiovascular health18.*