Healthy Methylation Is Like A Symphony, Says This PhD Nutritionist & Musician

Methylation is a vital biochemical process that affects every cell in the body. It supports cardiovascular and cognitive function, energy and DNA production, detoxification pathways, and more. However, due to its vast impact on whole-body health, methylation can be quite difficult to comprehend or explain (even for a team of health editors!). 

The thing is, 50% of the U.S. population has a gene variant that makes their MTHFR enzyme work less efficiently, which means they're more likely to experience suboptimal methylation at some point in their life. Many of these individuals want to understand the ins and outs of methylation so they can know exactly how to promote healthy methylation cycles and overall well-being.

A symphony orchestra is a large group of up to 100 musicians that make up different sections, each playing a different type of instrument (i.e., string, woodwind, brass, and percussion).

String instruments include violins, violas, cellos, and double basses. These players make up more than half of the orchestra. "I love strings because they produce gorgeous backdrop harmonies and stunning melodies, too. They are foundational in most orchestral pieces," Ferira says.

Brass instruments include trumpets, trombones, tubas, and horns. The sounds that project from the brass section can be best described as bright and piercing, which is why they make a great representation of the methionine cycle.

Like the energetic brass instruments in an orchestra, the amino acid homocysteine is actively transformed (with the critical help of active 5-MTHF folate) into the amino acid methionine.* Ferira shares, "This junction is a climax in the methionine cycle, much like a brass instrument such as the trumpet might confidently call out with a bold musical motif, signifying a turning point or climax of the symphony."

Percussion instruments include a variety of drums, tympani, marimba, xylophones, gongs, chimes, tambourines, triangles, and more (even the piano!). To play percussion instruments well, precision is key.

"Executing complex rhythms is a nonnegotiable skill for percussionists," emphasizes Ferira. "Can you imagine a percussionist with no rhythm? It's funny." In stark contrast, "a methylation cycle that's off beat? Not funny at all."

In the symphony that is methylation, our percussion section delivers a precise, targeted set of instruments or tools that facilitate that critical, underlying rhythm. "These tools keep the tempo at all the critical intersections of the folate and methionine cycles. Our internal metronome, if you will," says Ferira.

While all players are important in a symphony, just as all parts of the methylation cycle are essential, remember that the string section (aka the MTHFR gene) is fundamental. So what would happen if, say, half or more of this foundational string section were off the beat?

"Imagine their rhythm is off," Ferira explains. "Try as the strings may to pluck along or play with their bows, their timing is off, and thus, they can't achieve the intended collective sound to support the other sections of the orchestra (folate and methionine cycles) and achieve the beautiful, optimized symphony (methylation)." Sure, some of the string instrumentalists will be able to perform fully and on the beat, but the others playing off beat are competing with the overall balance, and the musical piece doesn't sound like it should. How could it?

This is what occurs when an individual has an MTHFR gene variation. "Depending on the individual's MTHFR variant(s), more or less of the string section—those violinists, violists, cellists, and bassists—might be off the beat (up to 70%)," Ferira notes. 

If you have an MTHFR gene variant, you can ensure your string section is keeping time and not getting off beat by taking mbg's methylation B complex+ daily.* It's your pivotal percussion section. This gene-focused, precision nutrition solution promotes the best orchestral sound and rhythm for a full-on, beautiful symphony—i.e., methylation function and all the health actions that go along with it.*