The MTHFR Gene Mutation: What It Is + Why You Should Care

Your body is brilliantly complex. It contains more than 60,000 miles of blood vessels and creates 25 million new cells every second.

And yet it's easy to take for granted the profound wonder of what our bodies do to sustain us without us willing it.

Sadly, the health of our bodies is now being threatened by epidemic numbers of preventable chronic conditions. In fact, chronic diseases have surpassed infectious diseases as the top killer of humans. Modern culture, with all its advances in sanitation and technology, is also contributing to our undoing.

I have written in the past about how the unfortunate storm of modern environmental factors such as toxins, chronic stress, poor diet, and microbiome dysfunctions can trigger many of these health problems.

Plus, a study in the American Journal of Clinical Nutrition now suggests that the rapid changes in our environment over a relatively short period of time could be the main factor in chronic health problems. In other words, most of our genes were formed before the development of agriculture, around 10,000 years ago, and haven't had time to adjust. Our genes may be under attack from the world around us.

Methylation, a biochemical process, happens more than 1 billion times a second in your body to keep you alive and healthy.

In short, if methylation is not working well, a lot can go wrong with your health. Changes to these important genes make it difficult for your body to handle those environmental stressors I mentioned earlier.

There are many different methylation genes, but the most famous one is the MTHFR gene. Some estimate that as many as 40 percent of the world — including me — have a MTHFR mutation, although most don’t know it.

Research in this area is still emerging, and more needs to be done. But it's suggested that the more methylation impairments we might have, the bigger potential for health problems.

As a functional medicine practitioner, I wanted to take more time to work on supporting my own health. I started with a 60-day reset diet to deal with my food intolerances and then focused on my adrenal fatigue with a hormone-balancing protocol.

But while microbiome and hormone problems are reversible, MTHFR gene changes are not. That means supporting genetic weaknesses is not solved with 60 days of this or 90 days of that. These changes are lifelong.

If you have methylation mutations, you may want to seek the support of a qualified functional medicine practitioner. Since each methylation impairment responds to care differently, what works for you will be different, too.

Folate, which is found in greens like kale, collards, chard, and spinach, is needed for methylation. So I make sure to fill up every day on lots of nutritious greens.

Full of nutrients, cabbage, broccoli, cauliflower, onions, garlic, mushrooms, and asparagus also support methylation.

Excess glutamate (your excitatory neurotransmitter) relative to GABA (your calming neurotransmitter) is common with methylation impairments. Because of this, glutamate imbalances are linked with chronic fatigue and fibromyalgia. If you feel nervous, anxious, fatigued, or unable to sleep, an imbalance of glutamate to GABA may be an issue for you.

Vitamin B12 is crucial for methylation and for overall health. The best sources are usually grass-fed meat and animal products, but supplementation may be needed for methylation impairments. It's important to talk to your doctor first, since everyone will tolerate the various types of B12 (like Adenosyl B12, Cyano B12, Hydroxycobalamin B12, Methyl B12) differently. Some forms can make you jittery or nervous, and taking too much could exacerbate symptoms.

The bottom line: Navigating MTHFR mutations and other methylation impairments can be overwhelming. Consider a free evaluation to see if functional medicine might be right for you.